By Lori A. Erickson
Atlas of Endocrine Pathology offers a complete compendium of photomicrographs of universal and unusual entities in endocrine pathology. the quantity contains histologic positive aspects of standard good points, reactive stipulations, hyperplasia and tumors. the main useful diagnostic beneficial properties are illustrated to supply path and clues to the analysis of endocrine tumors. additionally, photomicrographs spotlight the main pertinent diagnostic good points in difficult diagnoses in endocrine pathology.
Authored by means of a nationally and across the world famous pathologist, Atlas of Endocrine Pathology is a vital studying instrument for these changing into conversant in the various entities encountered in endocrine pathology and a priceless reference for working towards pathologists confronted with difficult diagnoses in endocrine pathology.
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Additional resources for Atlas of Endocrine Pathology
In difficult cases, p27 protein and HBME-1 may be used to separate these two lesions. p27 shows higher expression in Graves disease compared with papillary thyroid carcinoma . HBME-1 usually is positive in papillary thyroid carcinoma and negative in papillary hyperplasia  Fig. 6 Graves disease (diffuse hyperplasia). The cells in Graves disease are tall columnar cells with basally located round nuclei amphophilic to eosinophilic cytoplasm. Occasional oncocytic cells may be seen in Graves disease, particularly with preoperative treatment, but the oncocytic change is very focal compared with the extensive oncocytic change in Hashimoto thyroiditis Fig.
2006;17(2):165–73. 14. Sakorafas GH, et al. Microscopic papillary thyroid cancer as an incidental finding in patients treated surgically for presumably benign thyroid disease. J Postgrad Med. 2007;53(1):23–6. 15. Harach HR, Franssila KO, Wasenius VM. Occult papillary carcinoma of the thyroid. A “normal” finding in Finland. A systematic autopsy study. Cancer. 1985;56(3):531–8. 16. Wada N, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection.
Two papillary thyroid microcarcinomas are seen in this gross photograph. Papillary thyroid microcarcinoma is defined as measuring 1 cm or less. This tumor often is an incidental finding in thyroid glands removed for benign disease . Autopsy and surgical series identify these tumors in 7–35 % and 7 % of cases, respectively [12–15]. Incidental, clinically occult tumors are less aggressive than those presenting clinically. If a tumor is clinically apparent, regardless of size, it is a clinical carcinoma and usually treated as such.